Audi S4 vs Mercedes-Benz E350
Side-by-side comparison from manufacturer specifications, NHTSA safety data, and live dealer listings.
Vehicles
Vehicles
2027 Mercedes-Benz E350
Overview
| Spec | Audi S4Premium | Mercedes-Benz E350E 350 4MATIC Sedan |
|---|---|---|
| Selected trim | Premium | E 350 4MATIC Sedan |
| Body style | Sedan | Sedan |
| Drivetrain | all wheel drive | all wheel drive |
| Fuel type | premium unleaded (recommended) | premium unleaded (recommended) |
| Transmission | 8-speed shiftable automatic | 9-speed automatic |
| Engine type | gas | mild hybrid |
| Model year | 2025 | 2027 |
Pricing & market
| Spec | Audi S4Premium | Mercedes-Benz E350E 350 4MATIC Sedan |
|---|---|---|
| MSRP | $54,900 | $0 (best) |
| For sale now | 0 | 0 |
Fuel economy & range
| Spec | Audi S4Premium | Mercedes-Benz E350E 350 4MATIC Sedan |
|---|---|---|
| Combined MPG | 24 MPG | 27 MPG (best) |
| City MPG | 20 MPG | 24 MPG (best) |
| Highway MPG | 29 MPG | 33 MPG (best) |
| Fuel tank | 15.3 gal | 17 gal (best) |
Performance
| Spec | Audi S4Premium | Mercedes-Benz E350E 350 4MATIC Sedan |
|---|---|---|
| Horsepower | 349 hp (best) | 255 hp |
| Torque | 369 lb-ft (best) | 295 lb-ft |
| Engine size | 3 L (best) | 2 L |
| Cylinders | V6 | I4 |
Size & capability
| Spec | Audi S4Premium | Mercedes-Benz E350E 350 4MATIC Sedan |
|---|---|---|
| Seating | 5 seats | 5 seats |
| Doors | 4 | 4 |
| Cargo volume | 12 cu ft (best) | — |
| Payload | 1,036 lbs (best) | — |
| Curb weight | 3,880 lbs (best) | 4,189 lbs |
| Wheelbase | 111 in | 117 in (best) |
| Length | 187.5 in | 195 in (best) |
| Width | 72.7 in | 74 in (best) |
| Height | 56.2 in | 58 in (best) |
Safety & recalls
| Spec | Audi S4Premium | Mercedes-Benz E350E 350 4MATIC Sedan |
|---|---|---|
| Rollover | 5 / 5 ★ (best) | — |
| Open recalls (YMM scope) | None reported | None reported |
Highlighted values indicate the better figure for that spec when a clear winner exists. Specs reflect the selected trim for each vehicle. Drag a vehicle header to reorder columns. MSRP and specifications are manufacturer data; listing prices and inventory come from live dealer listings. Safety ratings are from NHTSA.
Trim overview
All available trims with MSRP. The trim selected above is highlighted; comparison specs use that selection.
| Trim | Audi S4 | Mercedes-Benz E350 |
|---|---|---|
| 1 | Premium $54,900 MSRP(Currently comparing) | E 350 4MATIC Sedan $0 MSRP(Currently comparing) |
| 2 | Premium Plus $58,800 MSRP | E 350 RWD Sedan $0 MSRP |
| 3 | Prestige $61,500 MSRP | — |