Audi S4 vs Mercedes-Benz E350
Side-by-side comparison from manufacturer specifications, NHTSA safety data, and live dealer listings.
Vehicles
Vehicles
2027 Mercedes-Benz E350
Overview
| Spec | Audi S4Premium | Mercedes-Benz E350E 350 |
|---|---|---|
| Selected trim | Premium | E 350 |
| Body style | Sedan | Sedan |
| Drivetrain | all wheel drive | rear wheel drive |
| Fuel type | premium unleaded (recommended) | premium unleaded (required) |
| Transmission | 8-speed shiftable automatic | 9-speed shiftable automatic |
| Engine type | gas | mild hybrid |
| Model year | 2025 | 2027 |
Pricing & market
| Spec | Audi S4Premium | Mercedes-Benz E350E 350 |
|---|---|---|
| MSRP | $54,900 (best) | $65,200 |
| Lowest listing price | $25,423 (best) | — |
| Median listing price | $25,423 (best) | — |
| Highest listing price | $25,423 (best) | — |
| For sale now | 1 (best) | 0 |
Fuel economy & range
| Spec | Audi S4Premium | Mercedes-Benz E350E 350 |
|---|---|---|
| Combined MPG | 24 MPG | 28 MPG (best) |
| City MPG | 20 MPG | 25 MPG (best) |
| Highway MPG | 29 MPG | 33 MPG (best) |
| Fuel tank | 15.3 gal | 17.4 gal (best) |
Performance
| Spec | Audi S4Premium | Mercedes-Benz E350E 350 |
|---|---|---|
| Horsepower | 349 hp (best) | 255 hp |
| Torque | 369 lb-ft (best) | 295 lb-ft |
| Engine size | 3 L (best) | 2 L |
| Cylinders | V6 | I4 |
Size & capability
| Spec | Audi S4Premium | Mercedes-Benz E350E 350 |
|---|---|---|
| Seating | 5 seats | 5 seats |
| Doors | 4 | 4 |
| Cargo volume | 12 cu ft | 12.7 cu ft (best) |
| Payload | 1,036 lbs (best) | — |
| Curb weight | 3,880 lbs (best) | 4,134 lbs |
| Wheelbase | 111 in | 116.6 in (best) |
| Length | 187.5 in | 194.9 in (best) |
| Width | 72.7 in | 74 in (best) |
| Height | 56.2 in | 57.9 in (best) |
Safety & recalls
| Spec | Audi S4Premium | Mercedes-Benz E350E 350 |
|---|---|---|
| Rollover | 5 / 5 ★ (best) | — |
| Open recalls (YMM scope) | None reported | None reported |
Highlighted values indicate the better figure for that spec when a clear winner exists. Specs reflect the selected trim for each vehicle. Drag a vehicle header to reorder columns. MSRP and specifications are manufacturer data; listing prices and inventory come from live dealer listings. Safety ratings are from NHTSA.
Trim overview
All available trims with MSRP. The trim selected above is highlighted; comparison specs use that selection.
| Trim | Audi S4 | Mercedes-Benz E350 |
|---|---|---|
| 1 | Premium $54,900 MSRP(Currently comparing) | E 350 $65,200 MSRP(Currently comparing) |
| 2 | Premium Plus $58,800 MSRP | E 350 4MATIC $67,700 MSRP |
| 3 | Prestige $61,500 MSRP | — |
Live inventory
Audi S4 vs Mercedes-Benz E350 FAQ
- Which is better: 2025 Audi S4 or 2027 Mercedes-Benz E350?
- It depends on priorities. OpenDealer compares 2025 Audi S4 vs 2027 Mercedes-Benz E350 on MSRP, fuel economy, horsepower, seating, towing, NHTSA safety ratings, and live market prices so you can weigh the tradeoffs.
- Which costs less: 2025 Audi S4 or 2027 Mercedes-Benz E350?
- Based on starting MSRP, the 2025 Audi S4 starts lower at $54,900. Live Audi S4 listings start at $25,423.
- Which has better startingMsrp: 2025 Audi S4 or 2027 Mercedes-Benz E350?
- The 2025 Audi S4 leads on startingMsrp in this comparison (54,900).
- Which has better combinedMpg: 2025 Audi S4 or 2027 Mercedes-Benz E350?
- The 2027 Mercedes-Benz E350 leads on combinedMpg in this comparison (28).
- Which has better horsepower: 2025 Audi S4 or 2027 Mercedes-Benz E350?
- The 2025 Audi S4 leads on horsepower in this comparison (349).