Audi S4 vs Mercedes-Benz R350
Side-by-side comparison from manufacturer specifications, NHTSA safety data, and live dealer listings.
Vehicles
Vehicles
2012 Mercedes-Benz R350
Overview
| Spec | Audi S4Premium | Mercedes-Benz R350R350 4MATIC |
|---|---|---|
| Selected trim | Premium | R350 4MATIC |
| Body style | Sedan | Wagon |
| Drivetrain | all wheel drive | all wheel drive |
| Fuel type | premium unleaded (recommended) | premium unleaded (required) |
| Transmission | 8-speed shiftable automatic | 7-speed shiftable automatic |
| Engine type | gas | gas |
| Model year | 2025 | 2012 |
Pricing & market
| Spec | Audi S4Premium | Mercedes-Benz R350R350 4MATIC |
|---|---|---|
| MSRP | $54,900 | $52,690 (best) |
| Lowest listing price | $25,423 (best) | — |
| Median listing price | $25,423 (best) | — |
| Highest listing price | $25,423 (best) | — |
| For sale now | 1 (best) | 0 |
Fuel economy & range
| Spec | Audi S4Premium | Mercedes-Benz R350R350 4MATIC |
|---|---|---|
| Combined MPG | 24 MPG (best) | 18 MPG |
| City MPG | 20 MPG (best) | 16 MPG |
| Highway MPG | 29 MPG (best) | 21 MPG |
| Fuel tank | 15.3 gal | 21.1 gal (best) |
Performance
| Spec | Audi S4Premium | Mercedes-Benz R350R350 4MATIC |
|---|---|---|
| Horsepower | 349 hp (best) | 302 hp |
| Torque | 369 lb-ft (best) | 273 lb-ft |
| Engine size | 3 L | 3.5 L (best) |
| Cylinders | V6 | V6 |
Size & capability
| Spec | Audi S4Premium | Mercedes-Benz R350R350 4MATIC |
|---|---|---|
| Seating | 5 seats | 6 seats (best) |
| Doors | 4 | 5 (best) |
| Cargo volume | 12 cu ft | 85 cu ft (best) |
| Towing capacity | — | 3,500 lbs (best) |
| Payload | 1,036 lbs (best) | — |
| Curb weight | 3,880 lbs (best) | 4,960 lbs |
| Ground clearance | — | 5.8 in (best) |
| Wheelbase | 111 in | 126.6 in (best) |
| Length | 187.5 in | 203 in (best) |
| Width | 72.7 in | 77.1 in (best) |
| Height | 56.2 in | 65.4 in (best) |
Safety & recalls
| Spec | Audi S4Premium | Mercedes-Benz R350R350 4MATIC |
|---|---|---|
| Rollover | 5 / 5 ★ (best) | — |
| Open recalls (YMM scope) | None reported (best) | 3 |
Highlighted values indicate the better figure for that spec when a clear winner exists. Specs reflect the selected trim for each vehicle. Drag a vehicle header to reorder columns. MSRP and specifications are manufacturer data; listing prices and inventory come from live dealer listings. Safety ratings are from NHTSA.
Trim overview
All available trims with MSRP. The trim selected above is highlighted; comparison specs use that selection.
| Trim | Audi S4 | Mercedes-Benz R350 |
|---|---|---|
| 1 | Premium $54,900 MSRP(Currently comparing) | R350 4MATIC $52,690 MSRP(Currently comparing) |
| 2 | Premium Plus $58,800 MSRP | R350 BlueTEC $53,840 MSRP |
| 3 | Prestige $61,500 MSRP | — |
Live inventory
Audi S4 vs Mercedes-Benz R350 FAQ
- Which is better: 2025 Audi S4 or 2012 Mercedes-Benz R350?
- It depends on priorities. OpenDealer compares 2025 Audi S4 vs 2012 Mercedes-Benz R350 on MSRP, fuel economy, horsepower, seating, towing, NHTSA safety ratings, and live market prices so you can weigh the tradeoffs.
- Which costs less: 2025 Audi S4 or 2012 Mercedes-Benz R350?
- Based on starting MSRP, the 2012 Mercedes-Benz R350 starts lower at $52,690. Live Audi S4 listings start at $25,423.
- Which has better startingMsrp: 2025 Audi S4 or 2012 Mercedes-Benz R350?
- The 2012 Mercedes-Benz R350 leads on startingMsrp in this comparison (52,690).
- Which has better combinedMpg: 2025 Audi S4 or 2012 Mercedes-Benz R350?
- The 2025 Audi S4 leads on combinedMpg in this comparison (24).
- Which has better horsepower: 2025 Audi S4 or 2012 Mercedes-Benz R350?
- The 2025 Audi S4 leads on horsepower in this comparison (349).
- Which has better seats: 2025 Audi S4 or 2012 Mercedes-Benz R350?
- The 2012 Mercedes-Benz R350 leads on seats in this comparison (6).
- Which has better maxTowingLbs: 2025 Audi S4 or 2012 Mercedes-Benz R350?
- The 2012 Mercedes-Benz R350 leads on maxTowingLbs in this comparison (3,500).