Audi S5 vs Mercedes-Benz E450
Side-by-side comparison from manufacturer specifications, NHTSA safety data, and live dealer listings.
Vehicles
Vehicles
2027 Mercedes-Benz E450
Overview
| Spec | Audi S5Premium | Mercedes-Benz E450E 450 4MATIC |
|---|---|---|
| Selected trim | Premium | E 450 4MATIC |
| Body style | Hatchback | Sedan |
| Drivetrain | all wheel drive | all wheel drive |
| Fuel type | premium unleaded (recommended) | premium unleaded (required) |
| Transmission | 7-speed automated manual | 9-speed automatic |
| Engine type | gas | mild hybrid |
| Model year | 2026 | 2027 |
Pricing & market
| Spec | Audi S5Premium | Mercedes-Benz E450E 450 4MATIC |
|---|---|---|
| MSRP | $63,300 | $0 (best) |
| For sale now | 0 | 0 |
Fuel economy & range
| Spec | Audi S5Premium | Mercedes-Benz E450E 450 4MATIC |
|---|---|---|
| Combined MPG | 23 MPG | 25 MPG (best) |
| City MPG | 20 MPG | 22 MPG (best) |
| Highway MPG | 29 MPG | 31 MPG (best) |
| Fuel tank | 14.8 gal | 17 gal (best) |
Performance
| Spec | Audi S5Premium | Mercedes-Benz E450E 450 4MATIC |
|---|---|---|
| Horsepower | 362 hp | 375 hp (best) |
| Torque | 406 lb-ft (best) | 369 lb-ft |
| Engine size | 3 L | 3 L |
| Cylinders | V6 | I6 |
Size & capability
| Spec | Audi S5Premium | Mercedes-Benz E450E 450 4MATIC |
|---|---|---|
| Seating | 5 seats | 5 seats |
| Doors | 4 | 4 |
| Cargo volume | 37.5 cu ft (best) | — |
| Payload | 992 lbs (best) | — |
| Curb weight | 4,288 lbs (best) | 4,376 lbs |
| Wheelbase | 114 in | 117 in (best) |
| Length | 190.3 in | 195 in (best) |
| Width | 73.2 in | 74 in (best) |
| Height | 56.5 in | 58 in (best) |
Safety & recalls
| Spec | Audi S5Premium | Mercedes-Benz E450E 450 4MATIC |
|---|---|---|
| NHTSA overall | Not Rated | — |
| Frontal crash (driver) | Not Rated | — |
| Frontal crash (passenger) | Not Rated | — |
| Side crash (driver) | Not Rated | — |
| Side crash (passenger) | Not Rated | — |
| Side pole | Not Rated | — |
| Rollover | Not Rated | — |
| Open recalls (YMM scope) | None reported | None reported |
Highlighted values indicate the better figure for that spec when a clear winner exists. Specs reflect the selected trim for each vehicle. Drag a vehicle header to reorder columns. MSRP and specifications are manufacturer data; listing prices and inventory come from live dealer listings. Safety ratings are from NHTSA.
Trim overview
All available trims with MSRP. The trim selected above is highlighted; comparison specs use that selection.
| Trim | Audi S5 | Mercedes-Benz E450 |
|---|---|---|
| 1 | Premium $63,300 MSRP(Currently comparing) | E 450 4MATIC $0 MSRP(Currently comparing) |
| 2 | Premium Plus $66,200 MSRP | E 450 4MATIC All-Terrain Wagon $0 MSRP |
| 3 | Prestige $70,900 MSRP | — |