Audi S6 vs Mercedes-Benz CLS53 AMG
Side-by-side comparison from manufacturer specifications, NHTSA safety data, and live dealer listings.
Vehicles
Vehicles
2021 Mercedes-Benz CLS53 AMG
Overview
| Spec | Audi S6Premium | Mercedes-Benz CLS53 AMGAMG CLS 53 |
|---|---|---|
| Selected trim | Premium | AMG CLS 53 |
| Body style | Sedan | Sedan |
| Drivetrain | all wheel drive | all wheel drive |
| Fuel type | premium unleaded (required) | premium unleaded (required) |
| Transmission | 8-speed shiftable automatic | 9-speed shiftable automatic |
| Engine type | mild hybrid | mild hybrid |
| Model year | 2025 | 2021 |
Pricing & market
| Spec | Audi S6Premium | Mercedes-Benz CLS53 AMGAMG CLS 53 |
|---|---|---|
| MSRP | $75,900 (best) | $81,550 |
| For sale now | 0 | 0 |
Fuel economy & range
| Spec | Audi S6Premium | Mercedes-Benz CLS53 AMGAMG CLS 53 |
|---|---|---|
| Combined MPG | 22 MPG | 23 MPG (best) |
| City MPG | 19 MPG | 21 MPG (best) |
| Highway MPG | 27 MPG (best) | 26 MPG |
| Fuel tank | 19.3 gal | 21.1 gal (best) |
Performance
| Spec | Audi S6Premium | Mercedes-Benz CLS53 AMGAMG CLS 53 |
|---|---|---|
| Horsepower | 444 hp (best) | 429 hp |
| Torque | 442 lb-ft (best) | 384 lb-ft |
| Engine size | 2.9 L | 3 L (best) |
| Cylinders | V6 | I6 |
Size & capability
| Spec | Audi S6Premium | Mercedes-Benz CLS53 AMGAMG CLS 53 |
|---|---|---|
| Seating | 5 seats | 5 seats |
| Doors | 4 | 4 |
| Cargo volume | 13.7 cu ft (best) | 11.9 cu ft |
| Payload | 1,102 lbs (best) | — |
| Curb weight | 4,519 lbs | 4,456 lbs (best) |
| Ground clearance | — | 4.7 in (best) |
| Wheelbase | 115.3 in | 115.7 in (best) |
| Length | 195 in | 199.1 in (best) |
| Width | 74.3 in | 74.6 in (best) |
| Height | 56.9 in (best) | 56 in |
Safety & recalls
| Spec | Audi S6Premium | Mercedes-Benz CLS53 AMGAMG CLS 53 |
|---|---|---|
| NHTSA overall | Not Rated | — |
| Frontal crash (driver) | Not Rated | — |
| Frontal crash (passenger) | Not Rated | — |
| Side crash (driver) | Not Rated | — |
| Side crash (passenger) | Not Rated | — |
| Side pole | Not Rated | — |
| Rollover | Not Rated | — |
| Open recalls (YMM scope) | 1 | None reported (best) |
Highlighted values indicate the better figure for that spec when a clear winner exists. Specs reflect the selected trim for each vehicle. Drag a vehicle header to reorder columns. MSRP and specifications are manufacturer data; listing prices and inventory come from live dealer listings. Safety ratings are from NHTSA.
Trim overview
All available trims with MSRP. The trim selected above is highlighted; comparison specs use that selection.
| Trim | Audi S6 | Mercedes-Benz CLS53 AMG |
|---|---|---|
| 1 | Premium $75,900 MSRP(Currently comparing) | AMG CLS 53 $81,550 MSRP(Currently comparing) |
| 2 | Premium Plus $80,200 MSRP | — |
| 3 | Prestige $84,100 MSRP | — |
Audi S6 vs Mercedes-Benz CLS53 AMG FAQ
- Which is better: 2025 Audi S6 or 2021 Mercedes-Benz CLS53 AMG?
- It depends on priorities. OpenDealer compares 2025 Audi S6 vs 2021 Mercedes-Benz CLS53 AMG on MSRP, fuel economy, horsepower, seating, towing, NHTSA safety ratings, and live market prices so you can weigh the tradeoffs.
- Which costs less: 2025 Audi S6 or 2021 Mercedes-Benz CLS53 AMG?
- Based on starting MSRP, the 2025 Audi S6 starts lower at $75,900.
- Which has better startingMsrp: 2025 Audi S6 or 2021 Mercedes-Benz CLS53 AMG?
- The 2025 Audi S6 leads on startingMsrp in this comparison (75,900).
- Which has better combinedMpg: 2025 Audi S6 or 2021 Mercedes-Benz CLS53 AMG?
- The 2021 Mercedes-Benz CLS53 AMG leads on combinedMpg in this comparison (23).
- Which has better horsepower: 2025 Audi S6 or 2021 Mercedes-Benz CLS53 AMG?
- The 2025 Audi S6 leads on horsepower in this comparison (444).
- How do the NHTSA safety ratings compare for 2025 Audi S6 vs 2021 Mercedes-Benz CLS53 AMG?
- NHTSA overall crash-test ratings in this comparison: Audi S6 (Not Rated/5 NHTSA overall).