Audi S6 vs Mercedes-Benz E43 AMG
Side-by-side comparison from manufacturer specifications, NHTSA safety data, and live dealer listings.
Vehicles
Vehicles
2018 Mercedes-Benz E43 AMG
Overview
| Spec | Audi S6Premium | Mercedes-Benz E43 AMGAMG E 43 4MATIC |
|---|---|---|
| Selected trim | Premium | AMG E 43 4MATIC |
| Body style | Sedan | Sedan |
| Drivetrain | all wheel drive | all wheel drive |
| Fuel type | premium unleaded (required) | premium unleaded (required) |
| Transmission | 8-speed shiftable automatic | 9-speed shiftable automatic |
| Engine type | mild hybrid | gas |
| Model year | 2025 | 2018 |
Pricing & market
| Spec | Audi S6Premium | Mercedes-Benz E43 AMGAMG E 43 4MATIC |
|---|---|---|
| MSRP | $75,900 | $71,600 (best) |
| For sale now | 0 | 0 |
Fuel economy & range
| Spec | Audi S6Premium | Mercedes-Benz E43 AMGAMG E 43 4MATIC |
|---|---|---|
| Combined MPG | 22 MPG (best) | 21 MPG |
| City MPG | 19 MPG | 19 MPG |
| Highway MPG | 27 MPG (best) | 25 MPG |
| Fuel tank | 19.3 gal | 21.1 gal (best) |
Performance
| Spec | Audi S6Premium | Mercedes-Benz E43 AMGAMG E 43 4MATIC |
|---|---|---|
| Horsepower | 444 hp (best) | 396 hp |
| Torque | 442 lb-ft (best) | 384 lb-ft |
| Engine size | 2.9 L | 3 L (best) |
| Cylinders | V6 | V6 |
Size & capability
| Spec | Audi S6Premium | Mercedes-Benz E43 AMGAMG E 43 4MATIC |
|---|---|---|
| Seating | 5 seats | 5 seats |
| Doors | 4 | 4 |
| Cargo volume | 13.7 cu ft (best) | 13.1 cu ft |
| Payload | 1,102 lbs (best) | — |
| Curb weight | 4,519 lbs | 4,145 lbs (best) |
| Wheelbase | 115.3 in | 115.7 in (best) |
| Length | 195 in (best) | 194.6 in |
| Width | 74.3 in (best) | — |
| Height | 56.9 in | 57 in (best) |
Safety & recalls
| Spec | Audi S6Premium | Mercedes-Benz E43 AMGAMG E 43 4MATIC |
|---|---|---|
| NHTSA overall | Not Rated | — |
| Frontal crash (driver) | Not Rated | — |
| Frontal crash (passenger) | Not Rated | — |
| Side crash (driver) | Not Rated | — |
| Side crash (passenger) | Not Rated | — |
| Side pole | Not Rated | — |
| Rollover | Not Rated | — |
| Open recalls (YMM scope) | 1 (best) | 2 |
Highlighted values indicate the better figure for that spec when a clear winner exists. Specs reflect the selected trim for each vehicle. Drag a vehicle header to reorder columns. MSRP and specifications are manufacturer data; listing prices and inventory come from live dealer listings. Safety ratings are from NHTSA.
Trim overview
All available trims with MSRP. The trim selected above is highlighted; comparison specs use that selection.
| Trim | Audi S6 | Mercedes-Benz E43 AMG |
|---|---|---|
| 1 | Premium $75,900 MSRP(Currently comparing) | AMG E 43 4MATIC $71,600 MSRP(Currently comparing) |
| 2 | Premium Plus $80,200 MSRP | — |
| 3 | Prestige $84,100 MSRP | — |
Audi S6 vs Mercedes-Benz E43 AMG FAQ
- Which is better: 2025 Audi S6 or 2018 Mercedes-Benz E43 AMG?
- It depends on priorities. OpenDealer compares 2025 Audi S6 vs 2018 Mercedes-Benz E43 AMG on MSRP, fuel economy, horsepower, seating, towing, NHTSA safety ratings, and live market prices so you can weigh the tradeoffs.
- Which costs less: 2025 Audi S6 or 2018 Mercedes-Benz E43 AMG?
- Based on starting MSRP, the 2018 Mercedes-Benz E43 AMG starts lower at $71,600.
- Which has better startingMsrp: 2025 Audi S6 or 2018 Mercedes-Benz E43 AMG?
- The 2018 Mercedes-Benz E43 AMG leads on startingMsrp in this comparison (71,600).
- Which has better combinedMpg: 2025 Audi S6 or 2018 Mercedes-Benz E43 AMG?
- The 2025 Audi S6 leads on combinedMpg in this comparison (22).
- Which has better horsepower: 2025 Audi S6 or 2018 Mercedes-Benz E43 AMG?
- The 2025 Audi S6 leads on horsepower in this comparison (444).
- How do the NHTSA safety ratings compare for 2025 Audi S6 vs 2018 Mercedes-Benz E43 AMG?
- NHTSA overall crash-test ratings in this comparison: Audi S6 (Not Rated/5 NHTSA overall).