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Cadillac CT5 vs Lexus IS350

Side-by-side comparison from manufacturer specifications, NHTSA safety data, and live dealer listings.

Vehicles

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2026 Cadillac CT5

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2026 Lexus IS350

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Overview

SpecCadillac CT5Premium LuxuryLexus IS350350 F SPORT Design
Selected trimPremium Luxury350 F SPORT Design
Body styleSedanSedan
Drivetrainrear wheel driverear wheel drive
Fuel typepremium unleaded (recommended)premium unleaded (required)
Transmission10-speed shiftable automatic8-speed shiftable automatic
Engine typegasgas
Model year20262026

Pricing & market

SpecCadillac CT5Premium LuxuryLexus IS350350 F SPORT Design
MSRP$48,600$45,500 (best)
Lowest listing price$26,597 (best)—
Median listing price$39,771 (best)—
Highest listing price$60,837 (best)—
For sale now11 (best)0

Fuel economy & range

SpecCadillac CT5Premium LuxuryLexus IS350350 F SPORT Design
Combined MPG26 MPG (best)23 MPG
City MPG23 MPG (best)20 MPG
Highway MPG32 MPG (best)28 MPG
Fuel tank17 gal17.4 gal (best)

Performance

SpecCadillac CT5Premium LuxuryLexus IS350350 F SPORT Design
Horsepower237 hp311 hp (best)
Torque258 lb-ft280 lb-ft (best)
Engine size2 L3.5 L (best)
CylindersI4V6

Size & capability

SpecCadillac CT5Premium LuxuryLexus IS350350 F SPORT Design
Seating5 seats5 seats
Doors44
Cargo volume11.9 cu ft (best)10.8 cu ft
Curb weight3,663 lbs (best)3,792 lbs
Wheelbase116 in (best)110.2 in
Length193.8 in (best)185.8 in
Width74.1 in (best)72.4 in
Height57.2 in (best)56.5 in

Safety & recalls

SpecCadillac CT5Premium LuxuryLexus IS350350 F SPORT Design
NHTSA overall5 / 5 ★ (best)—
Frontal crash (driver)5 / 5 ★ (best)—
Frontal crash (passenger)5 / 5 ★ (best)—
Side crash (driver)5 / 5 ★ (best)—
Side crash (passenger)5 / 5 ★ (best)—
Side pole5 / 5 ★ (best)—
Rollover5 / 5 ★ (best)—
Open recalls (YMM scope)1None reported (best)

Highlighted values indicate the better figure for that spec when a clear winner exists. Specs reflect the selected trim for each vehicle. Drag a vehicle header to reorder columns. MSRP and specifications are manufacturer data; listing prices and inventory come from live dealer listings. Safety ratings are from NHTSA.

Trim overview

All available trims with MSRP. The trim selected above is highlighted; comparison specs use that selection.

TrimCadillac CT5Lexus IS350
1

Premium Luxury

$48,600 MSRP(Currently comparing)

350 F SPORT Design

$45,500 MSRP(Currently comparing)

2

Sport

$49,600 MSRP

350 F SPORT Design

$47,500 MSRP

3

V

$57,600 MSRP

350 F SPORT

$47,950 MSRP

4

V Blackwing

$97,600 MSRP

350 F SPORT

$49,950 MSRP

Live inventory

Cadillac CT511 for sale

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Cadillac CT5 vs Lexus IS350 FAQ

Which is better: 2026 Cadillac CT5 or 2026 Lexus IS350?
It depends on priorities. OpenDealer compares 2026 Cadillac CT5 vs 2026 Lexus IS350 on MSRP, fuel economy, horsepower, seating, towing, NHTSA safety ratings, and live market prices so you can weigh the tradeoffs.
Which costs less: 2026 Cadillac CT5 or 2026 Lexus IS350?
Based on starting MSRP, the 2026 Lexus IS350 starts lower at $45,500. Live Cadillac CT5 listings start at $26,597.
Which has better startingMsrp: 2026 Cadillac CT5 or 2026 Lexus IS350?
The 2026 Lexus IS350 leads on startingMsrp in this comparison (45,500).
Which has better combinedMpg: 2026 Cadillac CT5 or 2026 Lexus IS350?
The 2026 Cadillac CT5 leads on combinedMpg in this comparison (26).
Which has better horsepower: 2026 Cadillac CT5 or 2026 Lexus IS350?
The 2026 Cadillac CT5 leads on horsepower in this comparison (668).
How do the NHTSA safety ratings compare for 2026 Cadillac CT5 vs 2026 Lexus IS350?
NHTSA overall crash-test ratings in this comparison: Cadillac CT5 (5/5 NHTSA overall).