Cadillac CT5 vs Mercedes-Benz E450
Side-by-side comparison from manufacturer specifications, NHTSA safety data, and live dealer listings.
Vehicles
Vehicles
2027 Mercedes-Benz E450
Overview
| Spec | Cadillac CT5Premium Luxury | Mercedes-Benz E450E 450 4MATIC |
|---|---|---|
| Selected trim | Premium Luxury | E 450 4MATIC |
| Body style | Sedan | Sedan |
| Drivetrain | rear wheel drive | all wheel drive |
| Fuel type | premium unleaded (recommended) | premium unleaded (required) |
| Transmission | 10-speed shiftable automatic | 9-speed shiftable automatic |
| Engine type | gas | mild hybrid |
| Model year | 2026 | 2027 |
Pricing & market
| Spec | Cadillac CT5Premium Luxury | Mercedes-Benz E450E 450 4MATIC |
|---|---|---|
| MSRP | $48,600 (best) | $73,700 |
| Lowest listing price | $26,597 (best) | — |
| Median listing price | $41,702 (best) | — |
| Highest listing price | $60,837 (best) | — |
| For sale now | 14 (best) | 0 |
Fuel economy & range
| Spec | Cadillac CT5Premium Luxury | Mercedes-Benz E450E 450 4MATIC |
|---|---|---|
| Combined MPG | 26 MPG (best) | 25 MPG |
| City MPG | 23 MPG (best) | 22 MPG |
| Highway MPG | 32 MPG (best) | 31 MPG |
| Fuel tank | 17 gal | 17.4 gal (best) |
Performance
| Spec | Cadillac CT5Premium Luxury | Mercedes-Benz E450E 450 4MATIC |
|---|---|---|
| Horsepower | 237 hp | 375 hp (best) |
| Torque | 258 lb-ft | 369 lb-ft (best) |
| Engine size | 2 L | 3 L (best) |
| Cylinders | I4 | I6 |
Size & capability
| Spec | Cadillac CT5Premium Luxury | Mercedes-Benz E450E 450 4MATIC |
|---|---|---|
| Seating | 5 seats | 5 seats |
| Doors | 4 | 4 |
| Cargo volume | 11.9 cu ft | 12.7 cu ft (best) |
| Curb weight | 3,663 lbs (best) | 4,376 lbs |
| Wheelbase | 116 in | 116.6 in (best) |
| Length | 193.8 in | 194.9 in (best) |
| Width | 74.1 in (best) | 74 in |
| Height | 57.2 in | 57.9 in (best) |
Safety & recalls
| Spec | Cadillac CT5Premium Luxury | Mercedes-Benz E450E 450 4MATIC |
|---|---|---|
| NHTSA overall | 5 / 5 ★ (best) | — |
| Frontal crash (driver) | 5 / 5 ★ (best) | — |
| Frontal crash (passenger) | 5 / 5 ★ (best) | — |
| Side crash (driver) | 5 / 5 ★ (best) | — |
| Side crash (passenger) | 5 / 5 ★ (best) | — |
| Side pole | 5 / 5 ★ (best) | — |
| Rollover | 5 / 5 ★ (best) | — |
| Open recalls (YMM scope) | 1 | None reported (best) |
Highlighted values indicate the better figure for that spec when a clear winner exists. Specs reflect the selected trim for each vehicle. Drag a vehicle header to reorder columns. MSRP and specifications are manufacturer data; listing prices and inventory come from live dealer listings. Safety ratings are from NHTSA.
Trim overview
All available trims with MSRP. The trim selected above is highlighted; comparison specs use that selection.
| Trim | Cadillac CT5 | Mercedes-Benz E450 |
|---|---|---|
| 1 | Premium Luxury $48,600 MSRP(Currently comparing) | E 450 4MATIC $73,700 MSRP(Currently comparing) |
| 2 | Sport $49,600 MSRP | E 450 4MATIC All-Terrain $80,000 MSRP |
| 3 | V $57,600 MSRP | — |
| 4 | V Blackwing $97,600 MSRP | — |
Live inventory
Cadillac CT514 for sale
See all
Certified2020 Cadillac CT5
Premium Luxury
Crystal White Tricoat•Maple Sugar With Jet Black Accents62,842 mi$26,597Greensboro Auto Center
Greensboro, NC
Certified2023 Cadillac CT5
Luxury
Argent Silver Metallic•Jet Black with Jet Black Accents, Inteluxe Seats28,231 mi$32,533Bayway Cadillac of the Woodlands
The Woodlands, TX
New2026 Cadillac CT5
Sport
Black Raven•Jet Black With Jet Black Accents, Leather Seating Surfaces23 mi$60,837Huston Cadillac
Lake Wales, FL
New2026 Cadillac CT5
Premium Luxury
Black Raven23 mi$55,862Huston Cadillac
Lake Wales, FL
New2026 Cadillac CT5
Premium Luxury
Black Raven23 mi$53,737Huston Cadillac
Lake Wales, FL
Used2025 Cadillac CT5
Sport
Black Raven•Jet Black37,255 mi$43,632North Dallas Chrysler Dodge Jeep Ram
Dallas, TX
Cadillac CT5 vs Mercedes-Benz E450 FAQ
- Which is better: 2026 Cadillac CT5 or 2027 Mercedes-Benz E450?
- It depends on priorities. OpenDealer compares 2026 Cadillac CT5 vs 2027 Mercedes-Benz E450 on MSRP, fuel economy, horsepower, seating, towing, NHTSA safety ratings, and live market prices so you can weigh the tradeoffs.
- Which costs less: 2026 Cadillac CT5 or 2027 Mercedes-Benz E450?
- Based on starting MSRP, the 2026 Cadillac CT5 starts lower at $48,600. Live Cadillac CT5 listings start at $26,597.
- Which has better startingMsrp: 2026 Cadillac CT5 or 2027 Mercedes-Benz E450?
- The 2026 Cadillac CT5 leads on startingMsrp in this comparison (48,600).
- Which has better combinedMpg: 2026 Cadillac CT5 or 2027 Mercedes-Benz E450?
- The 2026 Cadillac CT5 leads on combinedMpg in this comparison (26).
- Which has better horsepower: 2026 Cadillac CT5 or 2027 Mercedes-Benz E450?
- The 2026 Cadillac CT5 leads on horsepower in this comparison (668).
- Which has better seats: 2026 Cadillac CT5 or 2027 Mercedes-Benz E450?
- The 2027 Mercedes-Benz E450 leads on seats in this comparison (7).
- How do the NHTSA safety ratings compare for 2026 Cadillac CT5 vs 2027 Mercedes-Benz E450?
- NHTSA overall crash-test ratings in this comparison: Cadillac CT5 (5/5 NHTSA overall).