Lexus RX450h+ vs Mercedes-Benz ML350
Side-by-side comparison from manufacturer specifications, NHTSA safety data, and live dealer listings.
Vehicles
Vehicles
2015 Mercedes-Benz ML350
Overview
| Spec | Lexus RX450h+450h+ Premium | Mercedes-Benz ML350ML 350 |
|---|---|---|
| Selected trim | 450h+ Premium | ML 350 |
| Body style | SUV | SUV |
| Drivetrain | all wheel drive | rear wheel drive |
| Fuel type | premium unleaded (recommended) | premium unleaded (required) |
| Transmission | continuously variable-speed automatic | 7-speed shiftable automatic |
| Engine type | plug-in hybrid | gas |
| Model year | 2026 | 2015 |
Pricing & market
| Spec | Lexus RX450h+450h+ Premium | Mercedes-Benz ML350ML 350 |
|---|---|---|
| MSRP | $65,230 | $48,300 (best) |
| For sale now | 0 | 0 |
Fuel economy & range
| Spec | Lexus RX450h+450h+ Premium | Mercedes-Benz ML350ML 350 |
|---|---|---|
| Combined MPG | — | 20 MPG (best) |
| City MPG | — | 18 MPG (best) |
| Highway MPG | — | 24 MPG (best) |
| Combined MPGe | 85 MPGe (best) | — |
| Electric range | 38 mi (best) | — |
| Fuel tank | 14.5 gal | 24.6 gal (best) |
Performance
| Spec | Lexus RX450h+450h+ Premium | Mercedes-Benz ML350ML 350 |
|---|---|---|
| Horsepower | 304 hp (best) | 302 hp |
| Torque | — | 273 lb-ft (best) |
| Engine size | 2.5 L | 3.5 L (best) |
| Cylinders | I4 | V6 |
Size & capability
| Spec | Lexus RX450h+450h+ Premium | Mercedes-Benz ML350ML 350 |
|---|---|---|
| Seating | 5 seats | 5 seats |
| Doors | 4 | 4 |
| Cargo volume | 46.2 cu ft | 80.3 cu ft (best) |
| Towing capacity | 3,500 lbs (best) | — |
| Payload | 1,175 lbs (best) | — |
| Curb weight | 4,810 lbs (best) | — |
| Ground clearance | 8.1 in (best) | — |
| Wheelbase | 112.2 in | 114.8 in (best) |
| Length | 192.5 in (best) | 189.1 in |
| Width | 75.6 in | 84.3 in (best) |
| Height | 67.3 in | 70.7 in (best) |
Safety & recalls
| Spec | Lexus RX450h+450h+ Premium | Mercedes-Benz ML350ML 350 |
|---|---|---|
| Open recalls (YMM scope) | None reported (best) | 5 |
Highlighted values indicate the better figure for that spec when a clear winner exists. Specs reflect the selected trim for each vehicle. Drag a vehicle header to reorder columns. MSRP and specifications are manufacturer data; listing prices and inventory come from live dealer listings. Safety ratings are from NHTSA.
Trim overview
All available trims with MSRP. The trim selected above is highlighted; comparison specs use that selection.
| Trim | Lexus RX450h+ | Mercedes-Benz ML350 |
|---|---|---|
| 1 | 450h+ Premium $65,230 MSRP(Currently comparing) | ML 350 $48,300 MSRP(Currently comparing) |
| 2 | 450h+ Luxury $71,860 MSRP | ML 350 4MATIC $50,800 MSRP |
Lexus RX450h+ vs Mercedes-Benz ML350 FAQ
- Which is better: 2026 Lexus RX450h+ or 2015 Mercedes-Benz ML350?
- It depends on priorities. OpenDealer compares 2026 Lexus RX450h+ vs 2015 Mercedes-Benz ML350 on MSRP, fuel economy, horsepower, seating, towing, NHTSA safety ratings, and live market prices so you can weigh the tradeoffs.
- Which costs less: 2026 Lexus RX450h+ or 2015 Mercedes-Benz ML350?
- Based on starting MSRP, the 2015 Mercedes-Benz ML350 starts lower at $48,300.
- Which has better startingMsrp: 2026 Lexus RX450h+ or 2015 Mercedes-Benz ML350?
- The 2015 Mercedes-Benz ML350 leads on startingMsrp in this comparison (48,300).
- Which has better combinedMpg: 2026 Lexus RX450h+ or 2015 Mercedes-Benz ML350?
- The 2015 Mercedes-Benz ML350 leads on combinedMpg in this comparison (20).
- Which has better electricRangeMi: 2026 Lexus RX450h+ or 2015 Mercedes-Benz ML350?
- The 2026 Lexus RX450h+ leads on electricRangeMi in this comparison (38).
- Which has better horsepower: 2026 Lexus RX450h+ or 2015 Mercedes-Benz ML350?
- The 2026 Lexus RX450h+ leads on horsepower in this comparison (304).
- Which has better maxTowingLbs: 2026 Lexus RX450h+ or 2015 Mercedes-Benz ML350?
- The 2026 Lexus RX450h+ leads on maxTowingLbs in this comparison (3,500).