How much does the 2022 Mercedes-Benz CLS450 cost?

The 2022 Mercedes-Benz CLS450 has a starting MSRP of $72,950. Trim pricing includes CLS 450 4MATIC from $72,950.

What is the fuel economy of the 2022 Mercedes-Benz CLS450?

The 2022 Mercedes-Benz CLS450 achieves up to 25 MPG combined (EPA estimate), depending on trim and configuration.

How much cargo space does the 2022 Mercedes-Benz CLS450 have?

The 2022 Mercedes-Benz CLS450 offers up to 11.9 cubic feet of cargo capacity, depending on trim and seating configuration.

How many trims does the 2022 Mercedes-Benz CLS450 come in?

The 2022 Mercedes-Benz CLS450 is available in 1 trim across Sedan body styles with all wheel drive.

2022 Mercedes-Benz CLS450

1 trim · Sedan

Starting MSRP

$72,950

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Pricing

How much should you pay for the Mercedes-Benz CLS450? Select a trim to update purchase and lease estimates.

MSRP by trim

$72,950

Starting MSRP

Purchase information

Based on CLS 450 4MATIC

Total price (CLS 450 4MATIC MSRP)

$72,950

Typical monthly

$1,444/mo

Avg. APR

7.00%

60-month loan estimate for good credit (rates as of 2026-07-11). Not a credit offer; actual APR varies by lender, credit, and dealer.

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Compare 2022 Mercedes-Benz CLS450 trims

CLS 450 4MATIC
MSRP
$72,950
Fuel economy (city/hwy)
22/30
Horsepower
362 hp
Torque
369 lb-ft
Engine
3L I6 mild hybrid
Seating
5
Drivetrain
AWD
Cargo (cu ft)
11.9
Max towing
—

Compare 2022 Mercedes-Benz CLS450 trim specifications
Spec	CLS 450 4MATIC
MSRP	$72,950
Fuel economy (city/hwy)	22/30
Horsepower	362 hp
Torque	369 lb-ft
Engine	3L I6 mild hybrid
Seating	5
Drivetrain	AWD
Cargo (cu ft)	11.9
Max towing	—

Manufacturer specifications by trim and drivetrain. Same trim names with different MSRPs are distinct FWD/AWD (or other drivetrain) configurations from the catalog. MSRP excludes destination fees, taxes, and dealer-installed options.

Full specifications

Engine & drivetrain

Engine type: mild hybrid
Fuel type: premium unleaded (required)
Cylinders: I6
Displacement: 3 L
Horsepower: 362 hp
Torque: 369 lb-ft
Transmission: 9-speed shiftable automatic
Drivetrain: all wheel drive

Dimensions

Body type: Sedan
Doors: 4
Seating: 5
Length: 198.8 in
Width: 73.8 in
Height: 56.6 in
Wheelbase: 115.7 in
Ground clearance: 3.9 in

Capacity & weight

Cargo capacity: 11.9 cu ft
Curb weight: 4,255 lbs
Fuel tank: 21.1 gal

Fuel economy & EV

Combined MPG: 25
City MPG: 22
Highway MPG: 30

Full specifications by trim
Spec	Value
Engine & drivetrain
Engine type	mild hybrid
Fuel type	premium unleaded (required)
Cylinders	I6
Displacement	3 L
Horsepower	362 hp
Torque	369 lb-ft
Transmission	9-speed shiftable automatic
Drivetrain	all wheel drive
Dimensions
Body type	Sedan
Doors	4
Seating	5
Length	198.8 in
Width	73.8 in
Height	56.6 in
Wheelbase	115.7 in
Ground clearance	3.9 in
Capacity & weight
Cargo capacity	11.9 cu ft
Curb weight	4,255 lbs
Fuel tank	21.1 gal
Fuel economy & EV
Combined MPG	25
City MPG	22
Highway MPG	30