How much does the 2021 Mercedes-Benz S500 cost?

The 2021 Mercedes-Benz S500 has a starting MSRP of $109,800. Trim pricing includes S 500 4MATIC from $109,800.

What is the fuel economy of the 2021 Mercedes-Benz S500?

The 2021 Mercedes-Benz S500 achieves up to 24 MPG combined (EPA estimate), depending on trim and configuration.

How much cargo space does the 2021 Mercedes-Benz S500 have?

The 2021 Mercedes-Benz S500 offers up to 12.9 cubic feet of cargo capacity, depending on trim and seating configuration.

How many trims does the 2021 Mercedes-Benz S500 come in?

The 2021 Mercedes-Benz S500 is available in 1 trim across Sedan body styles with all wheel drive.

2021 Mercedes-Benz S500

1 trim · Sedan

Starting MSRP

$109,800

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Pricing

How much should you pay for the Mercedes-Benz S500? Select a trim to update purchase and lease estimates.

MSRP by trim

$109,800

Starting MSRP

Purchase information

Based on S 500 4MATIC

Total price (S 500 4MATIC MSRP)

$109,800

Typical monthly

$2,174/mo

Avg. APR

7.00%

60-month loan estimate for good credit (rates as of 2026-07-12). Not a credit offer; actual APR varies by lender, credit, and dealer.

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Compare 2021 Mercedes-Benz S500 trims

S 500 4MATIC
MSRP
$109,800
Fuel economy (city/hwy)
20/29
Horsepower
429 hp
Torque
384 lb-ft
Engine
3L I6 mild hybrid
Seating
5
Drivetrain
AWD
Cargo (cu ft)
12.9
Max towing
—

Compare 2021 Mercedes-Benz S500 trim specifications
Spec	S 500 4MATIC
MSRP	$109,800
Fuel economy (city/hwy)	20/29
Horsepower	429 hp
Torque	384 lb-ft
Engine	3L I6 mild hybrid
Seating	5
Drivetrain	AWD
Cargo (cu ft)	12.9
Max towing	—

Manufacturer specifications by trim and drivetrain. Same trim names with different MSRPs are distinct FWD/AWD (or other drivetrain) configurations from the catalog. MSRP excludes destination fees, taxes, and dealer-installed options.

Full specifications

Engine & drivetrain

Engine type: mild hybrid
Fuel type: premium unleaded (required)
Cylinders: I6
Displacement: 3 L
Horsepower: 429 hp
Torque: 384 lb-ft
Transmission: 9-speed shiftable automatic
Drivetrain: all wheel drive

Dimensions

Body type: Sedan
Doors: 4
Seating: 5
Length: 208.2 in
Width: 76.9 in
Height: 59.2 in
Wheelbase: 126.6 in
Ground clearance: 5.1 in

Capacity & weight

Cargo capacity: 12.9 cu ft
Max cargo capacity: 12.9 cu ft
Curb weight: 4,610 lbs
Fuel tank: 22.1 gal

Fuel economy & EV

Combined MPG: 24
City MPG: 20
Highway MPG: 29

Full specifications by trim
Spec	Value
Engine & drivetrain
Engine type	mild hybrid
Fuel type	premium unleaded (required)
Cylinders	I6
Displacement	3 L
Horsepower	429 hp
Torque	384 lb-ft
Transmission	9-speed shiftable automatic
Drivetrain	all wheel drive
Dimensions
Body type	Sedan
Doors	4
Seating	5
Length	208.2 in
Width	76.9 in
Height	59.2 in
Wheelbase	126.6 in
Ground clearance	5.1 in
Capacity & weight
Cargo capacity	12.9 cu ft
Max cargo capacity	12.9 cu ft
Curb weight	4,610 lbs
Fuel tank	22.1 gal
Fuel economy & EV
Combined MPG	24
City MPG	20
Highway MPG	29