How much does the 2022 Lexus RX350 cost?

The 2022 Lexus RX350 has a starting MSRP of $45,920, ranging up to $53,200 for the top trim. Trim pricing includes 350 from $45,920; 350 F SPORT from $49,400.

What is the fuel economy of the 2022 Lexus RX350?

The 2022 Lexus RX350 achieves up to 23 MPG combined (EPA estimate), depending on trim and configuration.

How much cargo space does the 2022 Lexus RX350 have?

The 2022 Lexus RX350 offers up to 32.7 cubic feet of cargo capacity, depending on trim and seating configuration.

How much can the 2022 Lexus RX350 tow?

The 2022 Lexus RX350 has a maximum towing capacity of up to 3,500 pounds, depending on trim and equipment.

How many trims does the 2022 Lexus RX350 come in?

The 2022 Lexus RX350 is available in 2 trims (6 total configurations) across SUV body styles with front wheel drive, all wheel drive.

2022 Lexus RX350

2 trims · 6 configurations · SUV

Starting MSRP

$45,920 – $53,200

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Pricing

How much should you pay for the Lexus RX350? Select a trim to update purchase and lease estimates.

MSRP by trim

Select a trim to update the payment estimates. MSRP is for each trim's base configuration and excludes destination, taxes, and options.

Purchase information

Based on 350

Total price (350 MSRP)

$45,920

Typical monthly

$909/mo

Avg. APR

7.00%

60-month loan estimate for good credit (rates as of 2026-10-11). Not a credit offer; actual APR varies by lender, credit, and dealer.

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Compare 2022 Lexus RX350 trims

350
2 configurations
MSRP
$45,920 – $47,320
Fuel economy (city/hwy)
20/27
Horsepower
295 hp
Torque
268 lb-ft
Engine
3.5L V6 gas
Seating
5
Drivetrain
FWD
Cargo (cu ft)
32.7
Max towing
3,500 lbs
350 F SPORT
4 configurations
MSRP
$49,400 – $53,200
Fuel economy (city/hwy)
20/27
Horsepower
295 hp
Torque
268 lb-ft
Engine
3.5L V6 gas
Seating
5
Drivetrain
FWD
Cargo (cu ft)
32.7
Max towing
3,500 lbs

Compare 2022 Lexus RX350 trim specifications
Spec	3502 configurations	350 F SPORT4 configurations
MSRP	$45,920 – $47,320	$49,400 – $53,200
Fuel economy (city/hwy)	20/27	20/27
Horsepower	295 hp	295 hp
Torque	268 lb-ft	268 lb-ft
Engine	3.5L V6 gas	3.5L V6 gas
Seating	5	5
Drivetrain	FWD	FWD
Cargo (cu ft)	32.7	32.7
Max towing	3,500 lbs	3,500 lbs

Specifications shown for each trim’s base configuration; drivetrain, cab, and box options vary within a trim, and MSRP shows the full range. MSRP excludes destination fees, taxes, and dealer-installed options.

Full specifications

Shown for each trim's base configuration. Drivetrain, cab, and box options within a trim can change dimensions, capacities, and fuel economy.

Engine & drivetrain

Engine type: 350gas
350 F SPORTgas
Fuel type: 350premium unleaded (recommended)
350 F SPORTpremium unleaded (recommended)
Cylinders: 350V6
350 F SPORTV6
Displacement: 3503.5 L
350 F SPORT3.5 L
Horsepower: 350295 hp
350 F SPORT295 hp
Torque: 350268 lb-ft
350 F SPORT268 lb-ft
Transmission: 3508-speed shiftable automatic
350 F SPORT8-speed shiftable automatic
Drivetrain: 350front wheel drive
350 F SPORTfront wheel drive

Dimensions

Body type: 350SUV
350 F SPORTSUV
Doors: 3504
350 F SPORT4
Seating: 3505
350 F SPORT5
Length: 350192.5 in
350 F SPORT192.5 in
Width: 35074.6 in
350 F SPORT74.6 in
Height: 35067.7 in
350 F SPORT67.7 in
Wheelbase: 350109.8 in
350 F SPORT109.8 in
Ground clearance: 3508.2 in
350 F SPORT8.2 in

Capacity & weight

Cargo capacity: 35016 cu ft
350 F SPORT16 cu ft
Max cargo capacity: 35032.7 cu ft
350 F SPORT32.7 cu ft
Max towing: 3503,500 lbs
350 F SPORT3,500 lbs
Max payload: 3501,444 lbs
350 F SPORT1,444 lbs
Curb weight: 3504,222 lbs
350 F SPORT4,222 lbs
Fuel tank: 35019.2 gal
350 F SPORT19.2 gal

Fuel economy & EV

Combined MPG: 35023
350 F SPORT23
City MPG: 35020
350 F SPORT20
Highway MPG: 35027
350 F SPORT27

Full specifications by trim
Spec	350	350 F SPORT
Engine & drivetrain
Engine type	gas	gas
Fuel type	premium unleaded (recommended)	premium unleaded (recommended)
Cylinders	V6	V6
Displacement	3.5 L	3.5 L
Horsepower	295 hp	295 hp
Torque	268 lb-ft	268 lb-ft
Transmission	8-speed shiftable automatic	8-speed shiftable automatic
Drivetrain	front wheel drive	front wheel drive
Dimensions
Body type	SUV	SUV
Doors	4	4
Seating	5	5
Length	192.5 in	192.5 in
Width	74.6 in	74.6 in
Height	67.7 in	67.7 in
Wheelbase	109.8 in	109.8 in
Ground clearance	8.2 in	8.2 in
Capacity & weight
Cargo capacity	16 cu ft	16 cu ft
Max cargo capacity	32.7 cu ft	32.7 cu ft
Max towing	3,500 lbs	3,500 lbs
Max payload	1,444 lbs	1,444 lbs
Curb weight	4,222 lbs	4,222 lbs
Fuel tank	19.2 gal	19.2 gal
Fuel economy & EV
Combined MPG	23	23
City MPG	20	20
Highway MPG	27	27

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2022 Lexus RX350 FAQ

How much does the 2022 Lexus RX350 cost?: The 2022 Lexus RX350 has a starting MSRP of $45,920, ranging up to $53,200 for the top trim. Trim pricing includes 350 from $45,920; 350 F SPORT from $49,400.
What is the fuel economy of the 2022 Lexus RX350?: The 2022 Lexus RX350 achieves up to 23 MPG combined (EPA estimate), depending on trim and configuration.
How much cargo space does the 2022 Lexus RX350 have?: The 2022 Lexus RX350 offers up to 32.7 cubic feet of cargo capacity, depending on trim and seating configuration.
How much can the 2022 Lexus RX350 tow?: The 2022 Lexus RX350 has a maximum towing capacity of up to 3,500 pounds, depending on trim and equipment.
How many trims does the 2022 Lexus RX350 come in?: The 2022 Lexus RX350 is available in 2 trims (6 total configurations) across SUV body styles with front wheel drive, all wheel drive.