How much does the 2022 Mercedes-Benz E450 cost?

The 2022 Mercedes-Benz E450 has a starting MSRP of $62,750, ranging up to $75,750 for the top trim. Trim pricing includes E 450 4MATIC from $62,750; E 450 from $66,100; E 450 4MATIC All-Terrain from $68,400.

What is the fuel economy of the 2022 Mercedes-Benz E450?

The 2022 Mercedes-Benz E450 achieves up to 25 MPG combined (EPA estimate), depending on trim and configuration.

How much cargo space does the 2022 Mercedes-Benz E450 have?

The 2022 Mercedes-Benz E450 offers up to 64 cubic feet of cargo capacity, depending on trim and seating configuration.

How many trims does the 2022 Mercedes-Benz E450 come in?

The 2022 Mercedes-Benz E450 is available in 3 trims (6 total configurations) across Coupe and Convertible and Sedan and Wagon body styles with rear wheel drive, all wheel drive.

2022 Mercedes-Benz E450

3 trims · 6 configurations · Coupe, Convertible, Sedan, Wagon

Starting MSRP

$62,750 – $75,750

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Pricing

How much should you pay for the Mercedes-Benz E450? Select a trim to update purchase and lease estimates.

MSRP by trim

Select a trim to update the payment estimates. MSRP is for each trim's base configuration and excludes destination, taxes, and options.

Purchase information

Based on E 450 4MATIC

Total price (E 450 4MATIC MSRP)

$62,750

Typical monthly

$1,243/mo

Avg. APR

7.00%

60-month loan estimate for good credit (rates as of 2026-07-11). Not a credit offer; actual APR varies by lender, credit, and dealer.

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Compare 2022 Mercedes-Benz E450 trims

E 450 4MATIC
3 configurations
MSRP
$62,750 – $75,750
Fuel economy (city/hwy)
23/30
Horsepower
362 hp
Torque
369 lb-ft
Engine
3L I6 mild hybrid
Seating
5
Drivetrain
AWD
Cargo (cu ft)
13.1
Max towing
—
E 450
2 configurations
MSRP
$66,100 – $73,250
Fuel economy (city/hwy)
22/29
Horsepower
362 hp
Torque
369 lb-ft
Engine
3L I6 mild hybrid
Seating
4
Drivetrain
RWD
Cargo (cu ft)
10
Max towing
—
E 450 4MATIC All-Terrain
MSRP
$68,400
Fuel economy (city/hwy)
21/28
Horsepower
362 hp
Torque
369 lb-ft
Engine
3L I6 mild hybrid
Seating
7
Drivetrain
AWD
Cargo (cu ft)
64
Max towing
—

Compare 2022 Mercedes-Benz E450 trim specifications
Spec	E 450 4MATIC3 configurations	E 4502 configurations	E 450 4MATIC All-Terrain
MSRP	$62,750 – $75,750	$66,100 – $73,250	$68,400
Fuel economy (city/hwy)	23/30	22/29	21/28
Horsepower	362 hp	362 hp	362 hp
Torque	369 lb-ft	369 lb-ft	369 lb-ft
Engine	3L I6 mild hybrid	3L I6 mild hybrid	3L I6 mild hybrid
Seating	5	4	7
Drivetrain	AWD	RWD	AWD
Cargo (cu ft)	13.1	10	64
Max towing	—	—	—

Specifications shown for each trim’s base configuration; drivetrain, cab, and box options vary within a trim, and MSRP shows the full range. MSRP excludes destination fees, taxes, and dealer-installed options.

Full specifications

Shown for each trim's base configuration. Drivetrain, cab, and box options within a trim can change dimensions, capacities, and fuel economy.

Engine & drivetrain

Engine type: E 450 4MATICmild hybrid
E 450mild hybrid
E 450 4MATIC All-Terrainmild hybrid
Fuel type: E 450 4MATICpremium unleaded (required)
E 450premium unleaded (required)
E 450 4MATIC All-Terrainpremium unleaded (required)
Cylinders: E 450 4MATICI6
E 450I6
E 450 4MATIC All-TerrainI6
Displacement: E 450 4MATIC3 L
E 4503 L
E 450 4MATIC All-Terrain3 L
Horsepower: E 450 4MATIC362 hp
E 450362 hp
E 450 4MATIC All-Terrain362 hp
Torque: E 450 4MATIC369 lb-ft
E 450369 lb-ft
E 450 4MATIC All-Terrain369 lb-ft
Transmission: E 450 4MATIC9-speed shiftable automatic
E 4509-speed shiftable automatic
E 450 4MATIC All-Terrain9-speed shiftable automatic
Drivetrain: E 450 4MATICall wheel drive
E 450rear wheel drive
E 450 4MATIC All-Terrainall wheel drive

Dimensions

Body type: E 450 4MATICSedan
E 450Coupe
E 450 4MATIC All-TerrainWagon
Doors: E 450 4MATIC4
E 4502
E 450 4MATIC All-Terrain5
Seating: E 450 4MATIC5
E 4504
E 450 4MATIC All-Terrain7
Length: E 450 4MATIC194.3 in
E 450190.4 in
E 450 4MATIC All-Terrain194.8 in
Width: E 450 4MATIC73.7 in
E 45073.1 in
E 450 4MATIC All-Terrain71.7 in
Height: E 450 4MATIC57.8 in
E 45056.7 in
E 450 4MATIC All-Terrain58.9 in
Wheelbase: E 450 4MATIC115.7 in
E 450113.1 in
E 450 4MATIC All-Terrain115.7 in
Ground clearance: E 450 4MATIC3.8 in
E 4503.9 in
E 450 4MATIC All-Terrain—

Capacity & weight

Cargo capacity: E 450 4MATIC13.1 cu ft
E 45010 cu ft
E 450 4MATIC All-Terrain35 cu ft
Max cargo capacity: E 450 4MATIC—
E 450—
E 450 4MATIC All-Terrain64 cu ft
Curb weight: E 450 4MATIC4,222 lbs
E 4504,189 lbs
E 450 4MATIC All-Terrain4,530 lbs
Fuel tank: E 450 4MATIC21.1 gal
E 45017.4 gal
E 450 4MATIC All-Terrain21.1 gal

Fuel economy & EV

Combined MPG: E 450 4MATIC25
E 45025
E 450 4MATIC All-Terrain24
City MPG: E 450 4MATIC23
E 45022
E 450 4MATIC All-Terrain21
Highway MPG: E 450 4MATIC30
E 45029
E 450 4MATIC All-Terrain28

Full specifications by trim
Spec	E 450 4MATIC	E 450	E 450 4MATIC All-Terrain
Engine & drivetrain
Engine type	mild hybrid	mild hybrid	mild hybrid
Fuel type	premium unleaded (required)	premium unleaded (required)	premium unleaded (required)
Cylinders	I6	I6	I6
Displacement	3 L	3 L	3 L
Horsepower	362 hp	362 hp	362 hp
Torque	369 lb-ft	369 lb-ft	369 lb-ft
Transmission	9-speed shiftable automatic	9-speed shiftable automatic	9-speed shiftable automatic
Drivetrain	all wheel drive	rear wheel drive	all wheel drive
Dimensions
Body type	Sedan	Coupe	Wagon
Doors	4	2	5
Seating	5	4	7
Length	194.3 in	190.4 in	194.8 in
Width	73.7 in	73.1 in	71.7 in
Height	57.8 in	56.7 in	58.9 in
Wheelbase	115.7 in	113.1 in	115.7 in
Ground clearance	3.8 in	3.9 in	—
Capacity & weight
Cargo capacity	13.1 cu ft	10 cu ft	35 cu ft
Max cargo capacity	—	—	64 cu ft
Curb weight	4,222 lbs	4,189 lbs	4,530 lbs
Fuel tank	21.1 gal	17.4 gal	21.1 gal
Fuel economy & EV
Combined MPG	25	25	24
City MPG	23	22	21
Highway MPG	30	29	28